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Cloning Animals

 

In Biology, cloning refers to the creation of genetically identical copies of molecules, cells, or organisms. Although cloning is often considered a recent scientific development, animal cloning experiments have been conducted since the 1950s. Furthermore, cloning occurs naturally in some invertebrates and vertebrates, and is referred to as parthenogenesis (a form of asexual reproduction).

There are various different forms of ‘artificial cloning’, involving the copying of specific elements. Molecular cloning refers to the situation when a defined DNA sequence is isolated and multiple copies of it are produced in vivo. This procedure can be utilised for a variety of applications, but is primarily used for large-scale protein production.

Cellular cloning involves the replication of entire cells in order to derive a cell population from a single cell. This process can be surprisingly simple in unicellular organisms such as bacteria and yeast, but can be a much more arduous and complex process in higher organisms. Organism cloning refers to producing a cellular organism that is genetically identical to another.

Dolly was born on the 5th of July 1996, and was the first animal to be successfully cloned from an adult cell. Previous clones had been produced from embryonic cells. The success rate of animal cloning has been low, Dolly the sheep resulted from 227 cloned cells that created just 29 viable embryos these may include those of bird feeders.

Of these only three lambs were born, with only one, Dolly surviving. In 2003, Dolly developed a progressive lung disease and was put down following veterinary advice. Concerns have been raised that cloning from adult cells essentially creates a clone that is the same biological age at birth. This means that the cloned organism will age much more quickly than a natural variant and it is argued will be more susceptible to disease.

Since Dolly was successfully cloned, many other large mammals, including horses and bulls have been cloned, with cloning considered a promising tool for preserving endangered species. In 2001, the first clone of an endangered gaur (wild ox) was born. Noah was produced by fusing skin cells from a gaur that had died in 1993 with a cow’s ovum, which had been stripped of its genetic material.

Unfortunately, Noah died after just forty-eight hours after contracting a common bacterial infection. Since this time, successful clones have been produced of African wild cats, demonstrating the possibility of repopulating endangered (or extinct) species, although this raises serious ethical and practical difficulties.

If extinction or species endangerment occurred from loss of habitat or lack of resources, cloning does nothing to solve these issues and may even divert funds from conservation projects. Conservationists also highlight the fact that cloning does not alleviate problems of loss of genetic diversity due to inbreeding, and that the success rate of the technology is so low at present, that cloning should only be considered an experimental science.

The main obstacle in regenerating an extinct species is that the DNA needed for cloning needs to be in almost perfect condition. Similarly, cloning from a single specimen would not create a viable breeding population, allowing for naturalistic sexual reproduction. It is also questionable whether the animals would be able to catch their own prey for example, since parents are not available to teach the necessary survival techniques.